Eicosanoids and Radiation by Peter Polgar (English) Paperback Book

Description: Eicosanoids and Radiation by Peter Polgar Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary carÂ cinoma. Since that time, the concept that arachidonic acid metabolites may be inÂ volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respecÂ tively. Cyclooxygenase products consist of diverse products such as prostaÂ glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelssons extensive study of the metabolism of prosÂ taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autoc FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate.This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelssons extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids. Table of Contents 1. Prostaglandins and Radiation in Cell Culture.- 2. Effects of Gamma Irradiation on Prostaglandin Biosynthesis and Metabolism: Intact Tissue.- 3. Radiation-Induced Alterations in Cyclooxygenase Product Release: An Overview.- 4. Irradiation and Blood Vessel Prostaglandin Metabolism.- 5. Effect of Ultraviolet Radiation on Eicosanoid Metabolism of Cells in Culture.- 6. Effects of Ultraviolet Radiation on Eicosanoid Metabolism in Intact Skin.- 7. Protection Against Ionizing Radiation with Eicosanoids.- 8. Protection of Radiation Damage by Eicosanoids-Clinical Studies.- 9. Radiation-Induced Genetic Damage and the Prostaglandin System.- 10. Radiation, Lipid Peroxidation and the Role of Oxygen Radicals in Eicosanoid Metabolism.- 11. Radiobiology of Blood Vessels.- 12. Dermal Damage from Ultraviolet Radiation. Promotional Springer Book Archives Long Description Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car Details ISBN146128970X Pages 196 Series Prostaglandins, Leukotrienes, and Cancer Language English ISBN-10 146128970X ISBN-13 9781461289708 Media Book Format Paperback Series Number 5 Imprint Springer-Verlag New York Inc. Country of Publication United States Edited by Peter Polgar Birth 1938 Year 2012 Publication Date 2012-01-22 Short Title EICOSANOIDS & RADIATION SOFTCO Place of Publication New York, NY DOI 10.1007/978-1-4613-1723-4 UK Release Date 2012-01-22 AU Release Date 2012-01-22 NZ Release Date 2012-01-22 US Release Date 2012-01-22 Author Peter Polgar Illustrations XII, 196 p. Publisher Springer-Verlag New York Inc. Edition Description Softcover reprint of the original 1st ed. 1988 Alternative 9780898383614 DEWEY 612.01577 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96342631;

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