Description: PREFACE It is increasingly evident that polyunsaturated fatty acids (PUFA), which in the past were often believed to be mere components of cellular membranes of neural tissue, are actually major determinants of the functional properties of neural cells and are intimately involved in brain disease processes. The two families of PUFA, which are derived from the essential polyenes, linoleic (18:2w6) and a-linolenic (18:33) acids, constitute a major proportion (-30%) of the total fatty acids esterified to brain phospholipids. Each family is distributed in membranes in a highly specific manner with respect to brain region, cell type, and position within each of the phosphoglycerides. Unlike their behavior in other organs, the PUFA components of brain turn over slowly and are relatively resistant to dietary modification. Their unique distribution and stability suggest that they play an important role in determining the functional properties of neural cells. However, until recently very little was known regarding the precise nature of their involvement. A great deal of excitement has been generated by the increasing realization that PUFA and phospholipids play integral roles in transmission of signals across neural membranes. PUFA, and particularly arachidonic acid (AA), can act as second messeng
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Item Specifics
All returns accepted: ReturnsNotAccepted
Level: Advanced
Number of Pages: 454 Pages
Publication Name: Neurobiology of Essential Fatty Acids
Language: English
Publisher: Springer
Publication Year: 1992
Subject: Life Sciences / Neuroscience, Life Sciences / Biochemistry, Endocrinology & Metabolism
Type: Textbook
Subject Area: Science, Medical
Author: M. G. Murphy, N. G. . Bazan, G. Toffano
Series: Advances in Experimental Medicine and Biology Ser.
Format: Hardcover
