Description: Transporters in Drug Development : Discovery, Optimization, Clinical Study and Regulation, Hardcover by Sugiyama, Yuichi (EDT); Steffansen, Bente (EDT), ISBN 1461482283, ISBN-13 9781461482284, Like New Used, Free P&P in the UK Transporters in Drug Development is a corner stone in a high profil series on advances in pharmaceutical sciences initiated by AAPS, Springer and Professor Daan Crommelin as series Editor. Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation list chapters written by leading researchers in the transporter field from academia, pharmaceutical industry and medicines agencies. Th encompasses examples and advises on how membrane transporters can be dealt with in academic industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Methods and examples of in vitro characterization of single transporters in intestine, liver and kidney are described as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are discussed as well as the perspectives of applying targeted proteomics and mechanistic modelling in this process.
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Book Title: Transporters in Drug Development : Discovery, Optimization, Clini
Number of Pages: 317 Pages
Language: English
Publication Name: Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation
Publisher: Springer-Verlag New York Inc.
Publication Year: 2013
Subject: Medicine
Item Height: 235 mm
Item Weight: 6878 g
Type: Textbook
Author: Yuichi Sugiyama, Bente Steffansen
Subject Area: Chemical Engineering
Series: Aaps Advances in the Pharmaceutical Sciences Series
Item Width: 155 mm
Format: Hardcover
